Knight publishes research and presents on secretory proteins

Jefferson Knight, assistant professor of chemistry at the University of Colorado Denver, recently published a research paper in the American Chemical Society journal Biochemistry, “Hydrophobic contributions to the membrane docking of synaptotagmin 7 C2A domain: Mechanistic contrast between isoforms 1 and 7.”

Knight also presented the paper at the October 2012 Rocky Mountain Regional Meeting of the American Chemical Society in Westminster.

The study identifies key differences between the biophysical actions of two secretory proteins that are otherwise very similar, and contribute to differences between the secretion of insulin in the pancreas and the secretion of neurotransmitter in the brain. The study was co-authored with CU Denver postbaccalaureate Matthew Coffman, research technician Devin Brandt, and CU-Boulder professor Joe Falke.